Alzheimer’s Disease: Are Plaques and Tangles The Cause or The Effect?

Confusing correlation with causation is a basic error in reasoning. It’s sometimes easy to confuse a symptom as a cause, rather than an effect. A new paper published in the Journal of Neuroscience suggests that the plaques and tangles associated with Alzheimer’s disease are perhaps a side-effect of the disorder and not the cause of cognitive decline.

The press release below points out that a fortune has been spent on trying to prevent the formation of plaques and tangles under the assumption that they cause the brain to deteriorate – and perhaps this is misguided.

There are more than 26 million Alzheimer’s victims across the globe.

NEW BRUNSWICK, N.J. Karl Herrup thinks that the national research effort to understand Alzheimer’s disease has gone about as far as it can go with its current theories. And that’s not far enough.Alzheimer’s disease is an incurable, degenerative and eventually fatal disease that attacks cognitive function. It affects more than 26 million people around the world and is the most common form of dementia among people over the age of 65. Over the last three decades, most Alzheimer’s research has been governed by the amyloid cascade hypothesis.

The theory which holds that the beta-amyloid peptide is the key to the initiation and progression of the disease has had significant appeal as the peptide is the main ingredient of the disease-related plaques that are common in the brains of those affected.

Indeed, this persistent correlation has led researchers to spend many years and many millions of dollars looking for ways to prevent plaques as a way of treating, curing or preventing Alzheimer’s. In recent years, however, dozens of human clinical trials based on this theory have failed.

Herrup, the chair of the Department of Cell Biology and Neuroscience at Rutgers University, suggests an alternative perspective, which he has set forth in a paper published today in the Journal of Neuroscience.

Pointing out that age is the most important risk factor in the disease, he suggests a new hypothesis with age as the starting point. Age slows the brain’s agility and blunts its responses to change; on their own, however, age-related changes lead only to a slow ‘natural’ decline in cognitive function, Herrup says. He posits that while these changes might increase one’s risk of the Alzheimer’s, they do not cause the disease.Herrup believes three three key steps that are needed for an individual to progress from this natural path to the full spectrum of Alzheimer’s clinical symptoms: an initiating injury that is probably vascular in nature; an inflammatory response that is both chronic and unique to Alzheimer’s; and a cellular change of state, a one-way cell biological door that permanently alters the physiology of neurons and several other cell types in the Alzheimer’s disease brain.

The initiating injury might trigger a protective response in the brain cells, Herrup says. But the real problem is that in the elderly the response doesn’t know when to quit. It continues even after the injury itself subsides. In the end, the real damage is done by the persistence of the response and not by the injury itself.tangleA tangle from the brain of an Alzheimer’s patient.

Herrup hopes his new theory will stimulate discussion and open the way to new experimental and diagnostic advances. This new hypothesis, for example, emphasizes the value of anti-inflammatory approaches to the prevention of Alzheimer’s disease, Herrup says.

He concedes that the individual components of the model aren’t entirely new, but points out that by rearranging their order and shifting their priority, his view has enormous implications for modern Alzheimer’s research.

My hypothesis implies that beta-amyloid aggregation is not a central part of

Tangle

the biology of Alzheimer’s disease, Herrup says. It predicts that one can have plaques without having Alzheimer’s and that one can have Alzheimer’s without having plaques. Researchers should be cautious about following up these predictions, but since we’ve gone about as far as we can with our current hypothesis, we may have reached a point where too much caution is ill-advised. It’s time to re-imagine Alzheimer’s disease, so we can think creatively about treating it.Excerpted from It’s Time for a New Approach to Alzheimer’s

via It’s Time for a New Approach to Alzheimer’s Disease.

Suggested Read: Review of Senior Citizen Medical Alarms

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  129. With havin so much content and articles do you ever run into any issues of plagorism or copyright infringement? My website has a lot of unique content I’ve either created myself or outsourced but it appears a lot of it is popping it up all over the web without my agreement. Do you know any solutions to help reduce content from being ripped off? I’d really appreciate it.

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  202. I am really loving the theme/design of your website. Do you ever run into any web browser compatibility issues? A small number of my blog visitors have complained about my website not working correctly in Explorer but looks great in Opera. Do you have any ideas to help fix this issue?

  203. Today, I went to the beachfront with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She placed the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is entirely off topic but I had to tell someone!

  204. Awesome blog! Do you have any suggestions for aspiring writers? I’m planning to start my own website soon but I’m a little lost on everything. Would you propose starting with a free platform like WordPress or go for a paid option? There are so many options out there that I’m totally overwhelmed .. Any suggestions? Bless you!

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  207. When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get three emails with the same comment. Is there any way you can remove people from that service? Thank you!

  208. Hi there are using WordPress for your blog platform? I’m new to the blog world but I’m trying to get started and set up my own. Do you require any coding expertise to make your own blog? Any help would be really appreciated!

  209. When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get several e-mails with the same comment. Is there any way you can remove people from that service? Cheers!

  210. Hmm it appears like your blog ate my first comment (it was super long) so I guess I’ll just sum it up what I had written and say, I’m thoroughly enjoying your blog. I as well am an aspiring blog writer but I’m still new to everything. Do you have any helpful hints for first-time blog writers? I’d really appreciate it.

  211. I do not know if it’s just me or if perhaps everybody else encountering problems with your site. It appears like some of the written text on your posts are running off the screen. Can somebody else please comment and let me know if this is happening to them too? This may be a issue with my web browser because I’ve had this happen before. Kudos

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  213. Today, I went to the beach with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She placed the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is entirely off topic but I had to tell someone!

  214. Very good blog! Do you have any recommendations for aspiring writers? I’m hoping to start my own blog soon but I’m a little lost on everything. Would you suggest starting with a free platform like WordPress or go for a paid option? There are so many options out there that I’m totally confused .. Any recommendations? Thank you!

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  227. Today, I went to the beachfront with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is totally off topic but I had to tell someone!

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  241. Hi this is somewhat of off topic but I was wanting to know if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding know-how so I wanted to get advice from someone with experience. Any help would be enormously appreciated!

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  246. The other day, while I was at work, my sister stole my iphone and tested to see if it can survive a 25 foot drop, just so she can be a youtube sensation. My iPad is now destroyed and she has 83 views. I know this is totally off topic but I had to share it with someone!

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  255. With havin so much content and articles do you ever run into any issues of plagorism or copyright infringement? My website has a lot of exclusive content I’ve either created myself or outsourced but it seems a lot of it is popping it up all over the web without my permission. Do you know any solutions to help prevent content from being ripped off? I’d really appreciate it.

  256. My developer is trying to convince me to move to .net from PHP. I have always disliked the idea because of the expenses. But he’s tryiong none the less. I’ve been using Movable-type on various websites for about a year and am worried about switching to another platform. I have heard very good things about blogengine.net. Is there a way I can import all my wordpress content into it? Any kind of help would be greatly appreciated!

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  269. Hi there would you mind stating which blog platform you’re using? I’m planning to start my own blog soon but I’m having a hard time making a decision between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your layout seems different then most blogs and I’m looking for something completely unique. P.S My apologies for being off-topic but I had to ask!

  270. Yesterday, while I was at work, my sister stole my iphone and tested to see if it can survive a forty foot drop, just so she can be a youtube sensation. My apple ipad is now destroyed and she has 83 views. I know this is completely off topic but I had to share it with someone!

  271. My developer is trying to persuade me to move to .net from PHP. I have always disliked the idea because of the costs. But he’s tryiong none the less. I’ve been using WordPress on several websites for about a year and am concerned about switching to another platform. I have heard excellent things about blogengine.net. Is there a way I can transfer all my wordpress posts into it? Any help would be really appreciated!

  272. Hi there! I know this is somewhat off topic but I was wondering which blog platform are you using for this website? I’m getting fed up of WordPress because I’ve had problems with hackers and I’m looking at options for another platform. I would be fantastic if you could point me in the direction of a good platform.

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  279. Today, I went to the beachfront with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is totally off topic but I had to tell someone!

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  298. Today, while I was at work, my sister stole my iPad and tested to see if it can survive a 25 foot drop, just so she can be a youtube sensation. My iPad is now destroyed and she has 83 views. I know this is totally off topic but I had to share it with someone!

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